23.07.2012
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Announcements / Press Releases
RBM SARN Annual Constituencies Consultative Meeting [RBM SARN] — (English)
The Southern Africa Roll Back Malaria Network (SARN), supported by the RBM Secretariat and partners, will hold the SARN General Assembly Annual Constituencies Consultative Meeting to review progress in the implementation of the SARN Work Plan and country road maps. Participants will also discuss the SADC Malaria Strategic Framework (2007 - 2015) and the SADC Malaria Elimination Framework and share best practices in achieving progress towards the RBM targets and the MDGs...
RBM Roadmaps updates [RBM] — (English)
Angola and Zanzibar 2012 roadmaps...
Genetically Engineered Bacteria Prevent Mosquitoes from Transmitting Malaria [JHMRI news] — (English)
Researchers at the Johns Hopkins Malaria Research Institute have genetically modified a bacterium commonly found in the mosquito's midgut and found that the parasite that causes malaria in people does not survive in mosquitoes carrying the modified bacterium...
Global Fund and Ethiopia Sign Grant Agreements For US$ 424 Million [The Global Fund News release] — (English)
The Global Fund to Fight AIDS, Tuberculosis and Malaria and the Government of Ethiopia signed two grant agreements today for US$424 million with the aim of achieving universal coverage of HIV treatment and completely eliminating malaria deaths in Ethiopia by 2015...
Release of the Preliminary Report of the Independent Evaluation [The Global Fund Announcement] — (English)
The Global Fund to Fight AIDS, Tuberculosis and Malaria today made public a preliminary report of an independent evaluation of the pilot phase of the Affordable Medicines Facility–malaria, also known as AMFm...
Preliminary Report of the Independent Evaluation of AMFm Phase 1 [The Global Fund publication] — (English)
To date, AMFm has subsidized nearly 270 million ACT treatments. This global subsidy is financed through contributions of US$336 million from UNITAID, the governments of the United Kingdom and Canada, and the Bill & Melinda Gates Foundation. Technical support is provided by members of the Roll Back Malaria Partnership...
An innovative approach to fighting HIV/AIDS, tuberculosis and malaria [Friends of the Global Fund Africa] — (English)
It is expected that anyone who comes across this document will have a working understanding of the innovative structure of the Global Fund to Fight AIDS, Tuberculosis and Malaria and its strategic partnership with the private sector in particular. Considering that the private sector is for profit making, decision makers in the sector should be encouraged by the water tight, transparent and accountable system the Fund operates to partner with the Fund in addressing the three diseases which impacts on production at the end of the day....
XIX Internationsl AIDS Conference 2012 [aids2012.org] — (English)
Leaders from the worlds of science, diplomacy, politics, philanthropy and entertainment are speaking at AIDS 2012...
WHO WPRO: Medical Officer (Malaria, and other Vectorborne and Parasitic Diseases) [WPRO] — (English)
View vacancy notice from WPRO...
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Articles requiring subscription or registration
Pathogen genomics: Within-host sequencing of malaria parasites [Nature Reviews Genetics 13, 519 (August 2012)] — (English)Deep sequencing was used to analyse Plasmodium falciparum DNA using blood samples from patients with malaria across Africa, Asia and Oceania. These data were used to develop a measurement of within-host parasite diversity that relates to the level of inbreeding and that is an important factor in the evolution of drug resistance...
Resisting resistance [Nature Reviews Microbiology 10, 524 (August 2012) | doi:10.1038/nrmicro2847] — (English)
This month's Genome Watch describes how knowledge of the malaria parasite genome can be used to better understand and mitigate the emergence of drug resistance...
Fighting malaria with engineered symbiotic bacteria from vector mosquitoes [PNAS] — (English)
Here, we describe a strategy that uses symbiotic bacteria to deliver antimalaria effector molecules to the midgut lumen, thus rendering host mosquitoes refractory to malaria infection...
Procalcitonin and C-reactive protein as predictors of blood culture positivity among hospitalised children with severe pneumonia in Mozambique [Tropical Medicine & International Health DOI: 10.1111/j.1365-3156.2012.03035.x] — (English)
Among hospitalised children with CSP and absence of concurrent malaria, PCT pre-screening could help reduce the number of blood cultures and diagnosis costs by specifically targeting patients more likely to yield positive results...
New Ultrastructural Analysis of the Invasive Apparatus of the Plasmodium Ookinete [Am J Trop Med Hyg, doi: 10.4269/ajtmh.2012.11-0609] — (English)
Here, we show higher-resolution ultrastructural details of developing and mature P. gallinaceum ookinetes than previously available...
Rapid diagnostic tests can extend access of diagnostic services for uncomplicated Plasmodium falciparum malaria [Int. J. Epidemiol. (2012) 41 (3): 607-610. doi: 10.1093/ije/dys083] — (English)
In this issue, we feature the Cochrane Diagnostic Review on Rapid diagnostic tests for diagnosing uncomplicated Plasmodium falciparum malaria in endemic countries, conducted by Abba et al. This column highlights Cochrane Reviews of relevance to public health, and aims to stimulate debate on relevance, feasibility and acceptability. We asked Emmanuel Bottieau and colleagues to comment on and put the review in context, and Mariska Leeflang provides an overview of the approach to conducting diagnostic reviews...
Emerging drugs for malaria [INFORMA, doi:10.1517/14728214.2012.702754] — (English)
Although promising compounds are presently undergoing clinical evaluation, the lack of new treatments for severe malaria and the predominance of artemisinin-based combination therapy for uncomplicated malaria is concerning. Future research should be directed towards the discovery of new therapeutic principles...
An unusual case of Plasmodium vivax malaria monoinfection associated with crescentic glomerulonephritis: a need for vigilance [PARASITOLOGY RESEARCH 2012, DOI: 10.1007/s00436-012-3040-5] — (English)
This case highlights the need to thoroughly search for malaria-associated crescentic glomerulonephritis using renal biopsy after nonrecovering renal failure...
Iron and Malaria Interactions: Research Needs From Basic Science to Global Policy [doi: 10.3945/an.111.001230 Adv Nutr July 2012 Adv Nutr vol. 3: 583-591, 2012] — (English)
This paper highlights some of the key questions under 5 headings: basic science; clinical science and epidemiology; technological developments; country level planning; and global policy...
Iron and Malaria Interactions: Programmatic Ways Forward [doi: 10.3945/an.111.000885 Adv Nutr July 2012 Adv Nutr vol. 3: 579-582, 2012] — (English)
Around one-quarter of the world's children suffer from iron deficiency anemia, and many of them live in malaria-endemic areas...
Implications of Malaria On Iron Deficiency Control Strategies [doi: 10.3945/an.111.001156 Adv Nutr July 2012 Adv Nutr vol. 3: 570-578, 2012] — (English)
Our improved understanding of iron metabolism may contribute to the control of malaria and the treatment of anemia. Malaria surveillance and control are necessary components of programs to control iron deficiency and may enhance the efficacy of iron supplementation...
Targeted provision of oral iron: the evolution of a practical screening option [doi: 10.3945/an.111.001149 Adv Nutr July 2012 Adv Nutr vol. 3: 560-569, 2012] — (English)
Universal oral iron supplementation, undertaken according to 1998 WHO guidelines, produced adverse consequences among some children in malaria-endemic areas...
Safety of Universal Provision of Iron through Home Fortification of Complementary Foods in Malaria-Endemic Areas [doi: 10.3945/an.111.001131 Adv Nutr July 2012 Adv Nutr vol. 3: 555-559, 2012] — (English)
Results from 6 home fortification studies in malaria-endemic areas showed no increased risk of morbidity (including malaria), but these studies were not powered to rule out a modest increase in the risk of severe adverse events. At present, the safest option is to implement home fortification in the context of comprehensive malaria control strategies, as recommended in recent WHO guidelines...
Iron deficiency and anemia control for infants and young children in malaria-endemic areas: a call to action and consensus among the research community [doi: 10.3945/an.111.000760 Adv Nutr July 2012 Adv Nutr vol. 3: 551-554, 2012] — (English)
WHO recommendations on iron supplementation for infants and young children in malaria-endemic areas changed dramatically from universal to targeted supplementation for iron-deficient children only, after a trial in a high malaria transmission area showed an increased risk of hospital admission and mortality among iron-replete children following iron and folic acid supplementation...
Thrombocytopenia as an Indicator of Malaria in Adult Population [Malaria Research and Treatment Volume 2012 (2012), Article ID 405981, 4 pages doi:10.1155/2012/405981] — (English)
The presence of thrombocytopenia may be a predictor of malaria in adult population...