2.07.2012
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Announcements / Press Releases
MMV: Intern, Human Resources [MMV] — (English)2012 Country Roadmaps June Updates [RBM] — (English)
Tanzania...
Malaria experts join forces with Novartis to empower local communities to tackle malaria in Africa [Novartis Press Release] — (English)
The Novartis Malaria Initiative is convening global experts from education, government, community health and economics to share best practices and empower local African communities to deliver sustainable malaria healthcare. Roll Back Malaria, the World Health Organization, World Bank and the African Leaders Malaria Alliance are highlighting the urgent need to ensure malaria remains a priority in the current economic climate...
Rio+20 declares health key to sustainable development [WHO] — (English)
The United Nations Conference on Sustainable Development (Rio+20) has adopted a series of measures that have the potential to contribute to a more equitable, cleaner, greener, and more prosperous world – and recognizes the important linkages between health and development...
MMV Annual Report 2011 [MMV] — (English)
Up-to-date articles highlighting MMV activities and the financial statement for 2011...
Accountability of Dr Margaret Chan during her first term as WHO Director-General [WHO] — (English)
This document sets out the Director General's assessment of achievements, setbacks, and remaining challenges, structured around the 22 specific promises made prior to her election...
Greece: MSF runs a malaria project [MSF] — (English)
The outbreak of malaria (Plasmodium vivax) among people with no travel history in 2011, after almost 40 years of absence in Greece, led to the decision for a comprehensive response from the international medical humanitarian organisation Médecins Sans Frontières (MSF). Following the reappearance of this "forgotten" disease in Greece, MSF started providing support to the Hellenic Centre for Disease Control and Prevention (HCDCP) for the development of an integrated preparedness and response national malaria plan...
The Global Fund, Angola and Chevron: together against malaria [The Global Fund Blog] — (English)
The Global Fund and Angola signed a US$56 million agreement in June which consolidated all current malaria grants in the country into a single grant. The goal of the program, which has been supported by Chevron, is to reduce malaria-related morbidity by 60% in Angola by 2016...
Restoring Global Economy amid Continuing Uncertainty Requires Courage to Take Difficult Decisions, Secretary-General Tells Economic and Social Council [UN News Centre] — (English)
Following are UN Secretary-General Ban Ki-moon's remarks at the high-level opening of the Economic and Social Council session in New York on 2 July...
President's Malaria Initiative E-Newsletter [PMI] — (English)
July issue...
Continuous LLIN Distribution Lessons in Brief [RBM VCWG] — (English)
Issues 1 to 5 of Continuous LLIN Distribution Lessons in Brief are now available also in French under Continuous LLIN Distribution Systems Work Stream Reference documents...
Report of the Joint SARN – PMI Mission to Zimbabwe [RBM SARNG] — (English)
The mission to Zimbabwe would be the first joint mission that would be used for assessing the value addition of these harmonized missions...
MMV: Associate Director, Clinical Development [MMV] — (English)
Application deadline: 15 July 2012...
Application deadline: 22 July 2012...
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Articles requiring subscription, registration etc.
Molecular basis of severe malari [PNAS June 26, 2012 vol. 109 no. 26 10130-10131] — (English)
Significant work has demonstrated that different forms of PfEMP1 display different adhesive properties, leading to a simple paradigm...
Prévention du paludisme : regard sur les pratiques des médecins généralistes réunionnais [] — (English)
According to these data, it seems important to promote networking between the doctors and the reference centers, which would enhance optimal practices concerning chemoprophylaxis and protection against mosquito bites, especially targeting the "at risk" patients...
Questionnaire-based analysis of atovaquone–proguanil compared with mefloquine in the chemoprophylaxis of malaria in non-immune Japanese travelers [JOURNAL OF INFECTION AND CHEMOTHERAPY 2012, DOI: 10.1007/s10156-012-0446-z] — (English)
These results suggest that A/P is better tolerated and has fewer adverse events than MEF in non-immune Japanese travelers...
Identification of the active region responsible for the anti-thrombotic activity of anopheline [informaHealthcare] — (English)
The aim of this study was to identify the active region of AAPP responsible for the anti-thrombotic activity because we hypothesized that AAPP could be used as a candidate anti-platelet drug. Various truncated forms of AAPP were produced using an Escherichia coli expression system...
Cytometric quantification of singlet oxygen in the human malaria parasite Plasmodium falciparum [Cytometry Part A DOI: 10.1002/cyto.a.22081] — (English)
In this study we visualized the generation of 1O2 by live cell fluorescence microscopy using 3-(p-aminophenyl) fluorescein as an indicator dye. While 1O2 is found restrictively in the parasite, its amount varies during erythrocytic schizogony...
Rational case management of malaria with a rapid diagnostic test, Paracheck Pf®, in antenatal health care in Bangui, Central African Republi [BMC Public Health 2012, 12:482 doi:10.1186/1471-2458-12-482] — (English)
Use of a rapid diagnostic test is useful, affordable and easy for adequate treatment of malaria in pregnant women. More powerful studies of the usefulness of introducing the test into antenatal care are needed in all heath centres in the country and in other tropical areas...
A simplified intravenous artesunate regimen for severe malaria [J Infect Dis. (2012) : jis391 doi: 10.1093/infdis/jis391] — (English)
Correspondance...
Reappraisal of the efficacy of a simplified artesunate regimen in falciparum malaria [J Infect Dis. (2012) : jis390 doi: 10.1093/infdis/jis390] — (English)
The authors examine key elements of the trial methodology in the context of established guidelines on the conduct and reporting of randomized controlled trials ...
Artesunate dosing in severe falciparum malaria [J Infect Dis. (2012) : jis389 doi: 10.1093/infdis/jis389] — (English)
Kremsner at al. conclude that "a simple 24‐hour, 3‐dose regimen should be further studied and developed to licensure for treating severe malaria in children". We think that this conclusion is not valid, and that it could be dangerous...
Cutting Edge: Clec9A+ Dendritic Cells Mediate the Development of Experimental Cerebral Malaria [The Journal of Immunology June 25, 2012 1201171] — (English)
Specifically, we have analyzed the in vivo contribution of this DC subset in an experimental CM model using Plasmodium berghei, and we provide strong evidence that the absence of this DC subset resulted in complete resistance to experimental CM...
Source of drug resistant Plasmodium falciparum in a potential malaria elimination site in Saudi Arabia [Infection, Genetics and Evolution Volume 12, Issue 6, August 2012, Pages 1253–1259] — (English)
The absence of mutations in dhps as well as triple mutant dhfr haplotype associated with SP failure support the current use of SP as a partner with artesunate as a first line therapy in Saudi Arabia. However, the close relationship between the major mutant dhfr haplotype in Sudan and Saudi Arabia, favour the hypothesis of recent migration as a source of the major resistant dhfr lineage...
Evaluation of a Web-Based Malaria Risk Reduction Game for Study Abroad Students [Journal of American College Health Volume 60, Issue 5, 2012] — (English)
The challenges of designing a feedback strategy to support Web-based learning make these results highly relevant to health educators developing interactive multimedia interventions...
Malaria elimination: moving forward with spatial decision support systems [Trends in Parasitology, Volume 28, Issue 7, July 2012, Pages 297–304] — (English)
Operational challenges facing contemporary malaria elimination have distinct geospatial elements including the need for high-resolution location-based surveillance, targeted prevention and response interventions, and effective delivery of essential services at optimum levels of coverage...
Aryl aryl methyl thio arenes prevent multidrug-resistant malaria in mouse by promoting oxidative stress in parasites [Free Radical Biology and Medicine Volume 53, Issue 1, 1 July 2012, Pages 129–142] — (English)
We have synthesized a new series of aryl aryl methyl thio arenes (AAMTAs) and evaluated antimalarial activity in vitro and in vivo against drug-resistant malaria...
Relationship between inflammatory mediator patterns and anemia in HIV-1 positive and exposed children with Plasmodium falciparum malaria [American Journal of Hematology Volume 87, Issue 7, pages 652–658, July 2012] — (English)
Results presented here demonstrate that there are unique relationships between the inflammatory environment and anemia in HIV-1 positive and exposed children with malaria...
Interleukin-10 (IL-10) Polymorphisms Are Associated with IL-10 Production and Clinical Malaria in Young Children [Infect. Immun. July 2012 vol. 80 no. 7 2316-2322] — (English)
The aims of this study were to investigate (i) whether genetic variants of the IL-10 gene influence IL-10 production and (ii) whether IL-10 production as well as the genotypes and haplotypes of the IL-10 gene in young children and their mothers are associated with the incidence of clinical malaria in young children...
Evaluating the frequency of bacterial co-infections in children recruited into a malaria pathogenesis study in The Gambia, West Africa using molecular methods [Molecular and Cellular Probes Volume 26, Issue 4, August 2012, Pages 151–158] — (English)
Here, we evaluated the usefulness of both broad-range 16S rRNA PCR, in conjunction with DNA sequencing and species-specific PCR targeting of Streptococcus pneumoniae and non-typhoidal Salmonella, to screen for bacterial co-infections in blood samples from children enrolled in a malaria pathogenesis study...
Bacteraemia in adult patients presenting with malaria in India [Acta Tropica Volume 123, Issue 2, August 2012, Pages 136–138] — (English)
This study has addressed this issue by enrolling 67 P. falciparum infected adult patients categorized into severe and uncomplicated malaria...
Efficacy and safety of atovaquone–proguanil in treating imported malaria in Japan: The second report from the research group [Parasitology International Volume 61, Issue 3, September 2012, Pages 466–469] — (English)
In the present study, additional cases of malaria were analyzed to confirm the efficacy and safety of this antimalarial drug...
Enhancement of naturally acquired immunity against malaria by drug use [J Med Microbiol July 2012 vol. 61 no. Pt 7 904-910] — (English)
We review the different ways in which antimalarial drugs have been used for prevention of malaria in endemic settings and discuss the possibilities and challenges of applying a strategy of drug use and naturally acquired infection in the field...
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