21.05.2012
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Announcements / Press Releases
Twenty-Second RBM Board Meeting [RBM] — (English)
View Twenty-Second RBM Board Meeting Decision Points. Visit RBM Flick Photo Gallery...
WHO and RBM launch Global Plan for Insecticide Resistance Management in malaria vectors [RBM & WHO] — (English)
The WHO Global Malaria Programme and the Roll Back Malaria Partnership have launched a global plan to tackle the emerging threat of mosquito resistance to insecticides...
Paludisme : du sang, de la sueur et des larmes [RBM, Malaria Consortium, Mairie de Paris, Sanifi] — (English)
L'exposition « Paludisme: du sang, de la sueur et des larmes » qui a été conçue et réalisée par le Malaria Consortium et le photojournaliste américain Adam Nadel, sera présentée pour la première fois en France à l'Hôtel de Ville de Paris du 18 mai au 2 juin 2012. Elle est organisée par la Mairie de Paris, le partenariat mondial Roll Back Malaria avec le soutien de Sanofi...
Last week Roadmaps Updates [RBM] — (English)
Uganda, Somalia et al....
New Discoveries About Severe Malaria Could Lead To New Interventions [Seattle BioMed, University of Copenhagen & University of Edinburgh] — (English)
Seattle BioMed, University of Copenhagen & University of Edinburgh report findings in PNAS...
Malaria Consortium: Business Development Manager [Malaria Consortium] — (English)
Application deadline: 28 May 2012...
Malaria Consortium: Country Director - Mozambique [Malaria Consortium] — (English)
Application deadline: 8 June 2012...
Centers for Disease Control and Prevention: Research Entomologist [CDC] — (English)
Application deadline: 15 June 2012...
Roll Back Malaria Partnership Secretariat Request for Expression of Interest: Resource Mobilization / External Relations Consultancy [RBM] — (English)
The Roll Back Malaria (RBM) Partnership Secretariat is inviting expressions of interest from individuals and consultancy firms to provide part-time support in 2012 in the areas of resource mobilization, advocacy and external relations...
Achieving Universal Diagnosis and Appropriate Case Management for Malaria [The United States Agency for International Development (USAID) and the President's Malaria Initiative (PMI)] — (English)
The United States Agency for International Development (USAID) and the President's Malaria Initiative (PMI) seek to award a five-year, $50,000,000.00 Cooperative Agreement, Achieving Universal Diagnosis and Appropriate Case Management for Malaria. USAID intends to support countries to expand high quality diagnosis and appropriate case management of malaria and related childhood illnesses, and possibly other priority infectious diseases. This activity will provide USAID, the Bureau for Global Health (GH), and the PMI with assistance to build the capacity of malaria-affected countries to provide high-quality diagnostic and treatment services for malaria and related childhood illnesses, and possibly other infectious diseases, at all levels of the health system and to provide global technical leadership on malaria diagnosis and case management...
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Articles requiring subscription
Poor-quality antimalarial drugs in southeast Asia and sub-Saharan Africa [he Lancet Infectious Diseases, Volume 12, Issue 6, Pages 488 - 496, June 2012] — (English)
Poor-quality antimalarial drugs lead to drug resistance and inadequate treatment, which pose an urgent threat to vulnerable populations and jeopardise progress and investments in combating malaria. Emergence of artemisinin resistance or tolerance in Plasmodium falciparum on the Thailand—Cambodia border makes protection of the effectiveness of the drug supply imperative...
Balancing act: haemoglobinopathies and malaria [] — (English)
More than 60 years have passed since J B S Haldane first suggested that the unusual distribution of Cooley's anaemia, the disorder now recognised as β-thalassaemia, might be explained by malaria...
Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis [The Lancet Infectious Diseases, Volume 12, Issue 6, Pages 457 - 468, June 2012 ] — (English)
We systematically searched the Medline and Embase databases for studies that estimated the risk of malaria in patients with and without haemoglobinopathies up to Sept 9, 2011, and identified additional studies from reference lists. We included studies that enrolled mainly children or pregnant women and had the following outcomes: Plasmodium falciparum severe malaria, uncomplicated malaria, asymptomatic parasitaemia, or pregnancy-associated malaria, and Plasmodium vivax malaria...
Liver-stage malaria parasites vulnerable to diverse chemical scaffolds [PNAS 10.1073/pnas.1118370109] — (English)
Further analysis of the hits in the Food and Drug Administration-approved drug subset revealed compounds that seem to act specifically on the liver stage of infection, suggesting that this phase of the parasite's life cycle presents a promising area for new drug discovery...
The effect of health education intervention on the home management of malaria among the caregivers of children aged under 5 years in Ogun State, Nigeria [European Journal of Medical Research 2012, 17:11 doi:10.1186/2047-783X-17-11] — (English)
The study design was a quasi-experimental study carried out in Ijebu North Local Government Area of Ogun State. A multistage random sampling technique was used in choosing the required samples for this study and a semi-structured questionnaire was used to collect relevant information...
Passive Immunoprotection of Plasmodium falciparum-Infected Mice Designates the CyRPA as Candidate Malaria Vaccine Antigen [The Journal of Immunology May 16, 2012 1103177] — (English)
Our data suggest a role for CyRPA in erythrocyte invasion by the merozoite. Inhibition of merozoite invasion by CyRPA-specific mAbs in vitro and in vivo renders this protein a promising malaria asexual blood-stage vaccine candidate Ag....
Limited Usefulness of Microsatellite Markers From the Malaria Vector Anopheles gambiae When Applied to the Closely Related Species Anopheles melas [J Hered (2012) doi: 10.1093/jhered/ess025] — (English)
We discuss the pitfalls of using microsatellite loci across closely related species and conclude that in addition to the problem of null alleles associated with this practice, many loci may prove to be of very limited use as polymorphic markers even when used in a sibling species...
Systems immunology of human malaria [Trends in Parasitology, 10.1016/j.pt.2012.03.006] — (English)
Here, we review the tools of systems immunology, their current limitations in the context of human malaria research, and the human 'models' of malaria immunity to which these tools can be applied...
Willingness-to-pay for a rapid malaria diagnostic test and artemisinin-based combination therapy from private drug shops in Mukono district, Uganda [Health Policy Plan. (2012) doi: 10.1093/heapol/czs048] — (English)
The findings further suggest that the WTP for an RDT and a course of ACT among drug shop customers is considerably lower than prevailing and estimated end-user prices for these commodities...
Exposure and health risk assessment of applicators to DDT during indoor residual spraying in malaria vector control program [Journal of Exposure Science and Environmental Epidemiology , (16 May 2012) | doi:10.1038/jes.2012.45] — (English)
We assessed exposure of applicators, health risk of DDT to the applicators and evaluated the applicability of existing pesticide exposure models for indoor residual spraying (IRS)...
Arterolane maleate and Piperaquine phosphate combination for the treatment of uncomplicated Plasmodium falciparum malaria: a comparative, multicentre randomized clinical trial [Clin Infect Dis. (2012) doi: 10.1093/cid/cis475] — (English)
The current study assessed the antimalarial efficacy and safety of a combination of 150 mg of arterolane maleate and 750 mg of piperaquine phosphate in comparison to Coartem® (artemether and lumefantrine) in patients with acute uncomplicated P. falciparum malaria...
Endoplasmic Reticulum Stress and Neurodegeneration in Experimental Cerebral Malaria [Neurosignals (DOI: 10.1159/000336970)] — (English)
These results implicate an imbalance between ER stress-mediated pro-apoptotic and anti-apoptotic/survival signalling as a critical determinant of neuronal cell death in ECM...