14.05.2012
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Announcements / Press Releases
Last week Roadmaps Updates [RBM] — (English)
Updates for Burundi, Comoros, Ghana, Madagascar...
Paludisme : du sang, de la sueur et des larmes [RBM, Malaria Consortium, Mairie de Paris, Sanifi] — (English)
L'exposition « Paludisme: du sang, de la sueur et des larmes » qui a été conçue et réalisée par le Malaria Consortium et le photojournaliste américain Adam Nadel, sera présentée pour la première fois en France à l'Hôtel de Ville de Paris du 18 mai au 2 juin 2012. Elle est organisée par la Mairie de Paris, le partenariat mondial Roll Back Malaria avec le soutien de Sanofi...
Exposition du «Swiss Malaria Group», Muséum d'histoire naturelle de la Ville de Genève [Swiss Malaria Group] — (English)
Du 15 mai au 9 septembre 2012, Muséum d'histoire naturelle de la ville de Genève...
Global Fund Forecasts $1.6 billion in Available Funds for 2012-2014 [The Global Fund Press Release] — (English)
Major Shift Reflects Strategic Choices by Board, Renewed Confidence...
Board of Global Fund Speeds Up Implementation of its Strategy [The Global Fund Press Release] — (English)
The Board of the Global Fund to Fight AIDS, Tuberculosis and Malaria concluded its 26th Meeting today with broad agreement to direct more than $1.6 billion in available funding into effective programs that save lives, accelerating implementation of the Board's ambitious strategy...
Evaluation of use of LLIN by pregnant women under Mo‐Mashari scheme and effectiveness of BCC messages on Malaria [RBM VCWG] — (English)
Report for VCWG Continuous LLIN Distribution Systems Work Stream...
SARN Reference Documents [RBM SARN] — (English)
Mozambique National Malaria Strategic Plan 2012-2016; National Malaria Policies (NMPs): Mozambique (2012); Namibia (2005); Swaziland (2010); SARN 2012 mission reports: Malawi, Namibia, Zimbabwe...
Roll Back Malaria Partnership Secretariat Request for Expression of Interest: Resource Mobilization / External Relations Consultancy [RBM] — (English)
The Roll Back Malaria (RBM) Partnership Secretariat is inviting expressions of interest from individuals and consultancy firms to provide part-time support in 2012 in the areas of resource mobilization, advocacy and external relations...
Achieving Universal Diagnosis and Appropriate Case Management for Malaria [The United States Agency for International Development (USAID) and the President's Malaria Initiative (PMI)] — (English)
The United States Agency for International Development (USAID) and the President's Malaria Initiative (PMI) seek to award a five-year, $50,000,000.00 Cooperative Agreement, Achieving Universal Diagnosis and Appropriate Case Management for Malaria. USAID intends to support countries to expand high quality diagnosis and appropriate case management of malaria and related childhood illnesses, and possibly other priority infectious diseases. This activity will provide USAID, the Bureau for Global Health (GH), and the PMI with assistance to build the capacity of malaria-affected countries to provide high-quality diagnostic and treatment services for malaria and related childhood illnesses, and possibly other infectious diseases, at all levels of the health system and to provide global technical leadership on malaria diagnosis and case management...
Malaria Atlas Project-Africa, Policy & Practice Manager [Kenya Medical Research Institute (KEMRI), Nairobi, Kenya] — (English)
Job description...
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Articles requiring subscription
Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000 [The Lancet, doi:10.1016/S0140-6736(12)60560-1] — (English)
We report the latest estimates of causes of child mortality in 2010 with time trends since 2000...
Malaria subsidy pilot soars, but some see turbulence ahead [Nature Medicine 18, 634–635 (2012) doi:10.1038/nm0512-634] — (English)
In 2010, a Kenyan drug importation and distribution company named Harley's Limited stopped ordering low-cost, mediocre malaria medications, and began ramping up its orders of high-quality ones—by about fourfold...
The effect of an integrated multisector model for achieving the Millennium Development Goals and improving child survival in rural sub-Saharan Africa: a non-randomised controlled assessment [The Lancet, doi:10.1016/S0140-6736(12)60207-4] — (English)
An integrated multisector approach for addressing the MDGs can lead to rapid improvement in child survival in rural sub-Saharan Africa...
Carcinogenicity of malaria and of some polyomaviruses [The Lancet Oncology, Vol. 13 No. 4 pp 339-340] — (English)
In February, 2012, 26 scientists from 11 countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to evaluate the carcinogenicity of malaria and of four polyomaviruses..
Plasmodium falciparum, anaemia and cognitive and educational performance among school children in an area of moderate malaria transmission: baseline results of a cluster randomized trial on the coast of Kenya [Tropical Medicine & International Health, Volume 17, Issue 5, pages 532–549, May 2012] — (English)
This study investigates the patterns of and risks for Plasmodium falciparum and anaemia and their association with cognitive and education outcomes on the Kenyan coast, an area of moderate malaria transmission...
Antigen persistence of rapid diagnostic tests in pregnant women in Nanoro, Burkina Faso, and the implications for the diagnosis of malaria in pregnancy [Tropical Medicine & International Health Volume 17, Issue 5, pages 550–557, May 2012] — (English)
Objective: to evaluate persistence of several Plasmodium antigens in pregnant women after treatment and compare diagnostics during treatment follow-up...
The Gates Malaria Partnership: a consortium approach to malaria research and capacity development [Tropical Medicine & International Health Volume 17, Issue 5, pages 558–563, May 2012] — (English)
Some of the lessons learnt during this project – such as the need to improve PhD supervision in African universities and to provide better support for postdoctoral fellows – are now being applied to a successor malaria research capacity development programme, the Malaria Capacity Development Consortium, and may be of interest to other groups involved in improving postgraduate training in health sciences in African universities...
Status of Plasmodium vivax malaria in the Republic of Korea, 2008–2009: decrease followed by resurgence [Transactions of the Royal Society of Tropical Medicine and Hygiene] — (English)
The number of Plasmodium vivax malaria cases in the Republic of Korea (ROK) in 2008 was 1009, a 54.2% decrease on the previous year...
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria [PNAS 10.1073/pnas.1205651109] — (English)
Here we present a unique generation of quinolone lead antimalarials with a dual mechanism of action against two respiratory enzymes, NADH:ubiquinone oxidoreductase (Plasmodium falciparum NDH2) and cytochrome bc1...
Case-report: Molecular diagnosis of Plasmodium knowlesi in a Dutch traveler by real-time PCR [JCM, May 2012, doi: 10.1128/JCM.06859-11] — (English)
P. knowlesi infection with low parasitemia forms a diagnostic challenge as rapid diagnostic tests often are negative, and species determination by microscopy is difficult. P. knowlesi malaria in a traveler is described and real-time PCR is demonstrated to support fast and reliable diagnosis and species determination...
Structural and Functional Insight Into How the Plasmodium falciparum VAR2CSA Protein Mediates Binding to Chondroitin Sulfate A in Placental Malaria [ doi: 10.1074/jbc.M112.348839 jbc.M112.348839] — (English)
VAR2CSA fragments based on the CSA binding region are potent vaccine candidates...
Relationship between inflammatory mediator patterns and anemia in HIV-1 positive and exposed children with Plasmodium falciparum malaria [Am. J. Hematol.] — (English)
Results presented here demonstrate that there are unique relationships between the inflammatory environment and anemia in HIV-1 positive and exposed children with malaria...
Reduced interferon (IFN)-α conditioned by IFNA2 (−173) and IFNA8 (−884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality [HUMAN GENETICS 2012, DOI: 10.1007/s00439-012-1175-1] — (English)
Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas...
Association of ABO blood group and P. falciparum malaria related outcomes: a cross-sectional study in Ethiopia [Acta Tropica] — (English)
This study examined association between ABO blood group and Plasmodium falciparum (P. falciparum) malaria related outcomes among 1065 malaria suspected febrile patients who attended Dore Baafano Health Center, southern Ethiopia, between December, 2010 and February, 2011...
Direct Manipulation of Malaria Parasites with Optical Tweezers Reveals Distinct Functions of Plasmodium Surface Proteins [ACS Nano, DOI: 10.1021/nn203616u] — (English)
Plasmodium sporozoite motility is essential for establishing malaria infections...
Development of humanized mouse models to study human malaria parasite infection [Future Microbiology, May 2012, Vol. 7, No. 5, Pages 657-665 , DOI 10.2217/fmb.12.27 (doi:10.2217/fmb.12.27)] — (English)
Here, we review the current state of research in this field and provide an outlook of the development of humanized small animal models to study P. falciparum infection that will accelerate fundamental research into human parasite biology and could accelerate drug and vaccine design in the future...
Metabolomic analysis of patient plasma yields evidence of plant-like α-linolenic acid metabolism in Plasmodium falciparum [J Infect Dis. (2012) doi: 10.1093/infdis/jis339] — (English)
Here, we used a liquid chromatography-mass spectrometry (LC-MS)-based approach to perform an untargeted metabolomic analysis of metabolite extracts from Plasmodium falciparum-infected and uninfected patient plasma samples, and an enriched population of in vitro cultured P. falciparum-infected and uninfected erythrocytes...
Therapeutic Efficacy of Artemether-Lumefantrine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Northern Ethiopia [Malaria Research and Treatment, Volume 2012 (2012), Article ID 548710, 6 pages doi:10.1155/2012/548710] — (English)
This prospective study was undertaken during August–November 2009 on 71 malaria patients that fulfilled the inclusion criteria set by the WHO...
IL-10 polymorphisms are associated with IL-10 production and clinical malaria in young children [IAI.00261-12 May 2012, doi: 10.1128/IAI.00261-12] — (English)
We genotyped three IL-10 single nucleotide polymorphisms in 240 children and their mothers from a longitudinal prospective cohort, and assessed the IL-10 production by maternal peripheral blood mononuclear cells (PBMCs) and cord blood mononuclear cells (CBMCs)...
HPLC Analysis of Stephania rotunda Extracts and Correlation with Antiplasmodial Activity [Issue Phytotherapy Research] — (English)
The aim of this study is to investigate the chemical composition and antiplasmodial activity of different samples of S. rotunda and compare their antiplasmodial activity with their alkaloid content...
Silica nanoparticle: a potential new insecticide for mosquito vector control [PARASITOLOGY RESEARCH 2012, DOI: 10.1007/s00436-012-2934-6] — (English)
Presently, there is a need for increased efforts to develop newer and effective methods to control mosquito vectors as the existing chemical and biological methods are not as effective as in earlier period owing to different technical and operational reasons...
Insecticidal and repellent activity of Hiptage benghalensis L. Kruz (Malpighiaceae) against mosquito vectors [PARASITOLOGY RESEARCH 2012, DOI: 10.1007/s00436-012-2925-7] — (English)
In the present study, larvicidal, adulticidal, and repellent activities of acetone root bark extract of Hiptage benghalensis were tested against the larvae and adults of the three mosquito vectors...